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Adiel Coca completed his PhD from Pennsylvania State University in 2007. He was a Visiting Assistant Professor at Franklin and Marshall College (Lancaster, PA) in 2007-2008. He then moved to Southern Connecticut State University (New Haven, CT) in 2008 where he is currently an Associate Professor. He was a Visiting Researcher at Oxford University (Oxford, UK) from July 2015 to January 2016. He currently has nine peer-reviewed publications and is serving as an editorial board member of the Journal of Modern Chemical Sciences.
Numerous applications have been reported for the tetrazole ring including being used as bioisosteres for carboxylic acids. In addition, several approved angiotensin II receptor antagonists that treat hypertension and congestive heart failure contain a tetrazole ring such as losartan, irbesartan, olmesartan, candesartan, valsartan and fimasartan. Some tetrazole derivatives have also been studied as propellants in airbags as well as in pyrotechnics and explosives due to the tendency of the tetrazole ring to decompose and release nitrogen gas under high heat. Our work involves the synthesis of 5-substituted 1H-tetrazole derivatives through the (3+2) cycloaddition of sodium azide with an organonitrile catalyzed by rare-earth metal catalysts. The reactions were carried out in an aqueous solvent mixture utilizing microwave heating. The antibacterial properties of tetrazole-containing compounds were also studied against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa.
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Prof. Aboul Ela is a graduate of Faculty of Pharmacy, University of Alexandria, Egypt. She has done her Ph.D. at Department of Pharmacognosy, Faculty of Pharmacy University of Alexandria in collaboration with Institute for Organic Chemistry, Technical University of Berlin, Germany. Her specialty is phytochemistry and phytotherapy. She had a postdoctoral fellow ship at School of Pharmacy, University of London, UK. Currently, she is the head of pharmaceutical sciences department, Faculty of Pharmacy, Beirut Arab University, Lebanon. She has more than sixty publications in national and international journals. She is a peer reviewer and editor in many international journals. She participated in various international conferences. She is a member of American Society of Pharmacognosy. She has more than 25 years experience in the field of education and research in pharmacognosy, phytochemistry and phytotherapy .She established the Junior Research Teams of the faculty in phytotherapy and medicinal chemistry. She supervises many theses. She started interdepartmental research collaboration at the faculty level. She is an expert in QA in Higher Education. She awarded a distinguishable peer reviewer from Ministry of Higher Education in Egypt. She attended and organized many workshops and lectures in the field of QA. She trained many academic, non academic staff and students in QA and accreditation requirements. She has got many awards from order of Pharmacists in Egypt and research at the national level in her specialty.
Various plants species are used in traditional folk medicine for their anti-diabetic, anti-cancer, anti-oxidant effects and for certain gastric disorders. Examples of plants are Papaver species which are well known for their diverse activities. Another example is Rosemarinus species that have been used in folk medicine for many purposes as diuretic, mild astringent, bitter tonic, digestive, emmenagogue and in cosmetics. Previous reports pointed out that, the activities of most of the examined plants are due to their contents of alkaloids, volatile oils and phenolic compounds obtained from their different extracts. Accordingly, this work comprises Phytochemical and pharmacological study on some selected Lebanese medicinal plants to investigate their constituents and explore their biological activities . The chemical structures of the isolated compounds, from the selected investigated plants belonging to different species, were determined by application of different spectroscopic techniques. Furthermore, the volatile oil constituents of the selected Lebanese plants were investigated. The biological activities of plants’ extracts revealed promising results. This work represents a collection of the research activities performed at the Department aiming to add more natural drug candidates, with potential biological activities, which could serve the pharmaceutical industry.