Scientific Program

Conference Series LLC Ltd invites all the participants across the globe to attend 2nd International Conference and Exhibition on Pharmaceutical Development and Technology Osaka, Japan.

Day 2 :

Pharma Tech 2018 International Conference Keynote Speaker Adiel Coca photo
Biography:

Adiel Coca completed his PhD from Pennsylvania State University in 2007. He was a Visiting Assistant Professor at Franklin and Marshall College (Lancaster, PA) in 2007-2008. He then moved to Southern Connecticut State University (New Haven, CT) in 2008 where he is currently an Associate Professor. He was a Visiting Researcher at Oxford University (Oxford, UK) from July 2015 to January 2016. He currently has nine peer-reviewed publications and is serving as an editorial board member of the Journal of Modern Chemical Sciences.         

Abstract:

Numerous applications have been reported for the tetrazole ring including being used as bioisosteres for carboxylic acids. In addition, several approved angiotensin II receptor antagonists that treat hypertension and congestive heart failure contain a tetrazole ring such as losartan, irbesartan, olmesartan, candesartan, valsartan and fimasartan. Some tetrazole derivatives have also been studied as propellants in airbags as well as in pyrotechnics and explosives due to the tendency of the tetrazole ring to decompose and release nitrogen gas under high heat. Our work involves the synthesis of 5-substituted 1H-tetrazole derivatives through the (3+2) cycloaddition of sodium azide with an organonitrile catalyzed by rare-earth metal catalysts. The reactions were carried out in an aqueous solvent mixture utilizing microwave heating. The antibacterial properties of tetrazole-containing compounds were also studied against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa.  

Pharma Tech 2018 International Conference Keynote Speaker Maha Aboul-Ela photo
Biography:

Prof. Aboul Ela is a graduate of Faculty of Pharmacy, University of Alexandria, Egypt. She has done her Ph.D. at Department of Pharmacognosy, Faculty of Pharmacy University of Alexandria in collaboration with Institute for Organic Chemistry, Technical University of Berlin, Germany. Her specialty is phytochemistry and phytotherapy. She had a postdoctoral fellow ship at School of Pharmacy, University of London, UK. Currently, she is the head of pharmaceutical sciences department, Faculty of Pharmacy, Beirut Arab University, Lebanon. She has more than sixty publications in national and international journals. She is a peer reviewer and editor in many international journals. She participated in various international conferences. She is a member of American Society of Pharmacognosy. She has more than 25 years experience in the field of education and research in pharmacognosy, phytochemistry and phytotherapy .She established the Junior Research Teams of the faculty in phytotherapy and medicinal chemistry. She supervises many theses. She started interdepartmental research collaboration at the faculty level. She is an expert in QA in Higher Education. She awarded a distinguishable peer reviewer from Ministry of Higher Education in Egypt. She attended and organized many workshops and lectures in the field of QA. She trained many academic, non academic staff and students in QA and accreditation requirements. She has got many awards from order of Pharmacists in Egypt and research at the national level in her specialty.

Abstract:

Various plants species are used in traditional folk medicine for their anti-diabetic, anti-cancer, anti-oxidant effects and for certain gastric disorders. Examples of plants are Papaver  species which are well known for their diverse activities. Another example is Rosemarinus species that have been used in folk medicine for many purposes as diuretic, mild astringent, bitter tonic, digestive, emmenagogue and in cosmetics. Previous reports pointed out that, the activities of most of the examined plants are due to their contents of  alkaloids, volatile oils and phenolic compounds obtained from their different extracts. Accordingly, this work comprises Phytochemical and pharmacological study on some selected Lebanese medicinal plants to investigate their constituents and explore their biological activities . The chemical structures of the isolated compounds, from the selected investigated plants belonging to different species, were determined by application of different spectroscopic techniques. Furthermore, the volatile oil constituents of the selected Lebanese plants were investigated. The biological activities of plants’ extracts revealed promising results. This work represents a collection of the research activities performed at the Department aiming to add more natural drug candidates, with potential biological activities, which could serve the pharmaceutical industry.

  • Drug Regulatory Affairs
Location: Hyatt Regency Osaka
Speaker
Biography:

Abdeen Mustafa Omer (BSc, MSc, PhD) is an Associate Researcher at Occupational Health Administration, Ministry of Health and Social Welfare, Khartoum, Sudan. He has been listed in the book WHO’S WHO in the World 2005, 2006, 2007 and 2010. He has published over 300 papers in peer-reviewed journals, 200 review articles, 7 books and 150 chapters in books

Abstract:

The strategy of price liberalisation and privatisation had been implemented in Sudan over the last decade, and has had a positive result on government deficit. The investment law approved recently has good statements and rules on the above strategy in particular to pharmacy regulations. Under the pressure of the new privatisation policy, the government introduced radical changes in the pharmacy regulations. To improve the effectiveness of the public pharmacy, resources should be switched towards areas of need, reducing inequalities and promoting better health conditions. Medicines are financed either through cost sharing or full private. The role of the private services is significant. A review of reform of financing medicines in Sudan is given in this article. Also, it highlights the current drug supply system in the public sector, which is currently responsibility of the Central Medical Supplies Public Corporation (CMS). In Sudan, the researchers did not identify any rigorous evaluations or quantitative studies about the impact of drug regulations on the quality of medicines and how to protect public health against counterfeit or low quality medicines, although it is practically possible. However, the regulations must be continually evaluated to ensure the public health is protected against by marketing high quality medicines rather than commercial interests, and the drug companies are held accountable for their conducts.

  • Pharmaceutical Research
Location: Hyatt Regency Osaka
Speaker
Biography:

Katrin Mae M. Ortega, a bonifide graduate in Master of Science in pharmacy at the age of 25 years from of University Of Santo Tomas last June 2017 wherein she was awarded a dsitinction of Cum Laude. During her graduate study, Ms Ortega exhibited top performance during written examination as well as oral examinations. She got a Meritus honor on her thesis entitled “Antiangiogenic and AMP-Activated Protein Kinase Activities of Gracilaria coronopifolia J.G. Agardh Extracts”. This study as awarded gold medal in the Technical Poster Competition during 2nd International Science Graduate Scholars” Conference in the theme “From Disccoveries Today to Innovating Tommorow” held at the Philippine International Convention  Center Pasay City. 

Abstract:

AMP-activated protein kinase (AMPK) is an intracellular energy sensor which is important in metabolic regulation, cell growth, and survival. Recently, dysfunction in AMPK is implicated to numerous angiogenesis-related diseases, however, the mechanism remains elusive. In this study, the antiangiogenic activity of the red alga, Gracilaria coronopifolia, was determined through cellular signaling pathway of AMPK. Chorioallantoic membrane (CAM) assay showed that all extracts of G. coronopifolia inhbited angiogenesis in a dose-dependent manner. Among them, dichloromethane extract exhibited the most potent antiangiogenic activity (IC50 =1.21 μg/mL, p=0.215) followed by hexane extract (IC50=3.08 μg/mL, p=0.479) and methanol extract (IC50=8.93 μg/mL, p= 0.042). Antiangiogenic activity was correlated to a low concentrations of Fe, Zn, and Cu of duck CAM determined using flame atomic absorption spectrometer (fAAS) and colorimetric assay. Likewise, In vitro AMPK signaling assay showed that all extracts activated AMPK, with dichloromethane extract having the lowest EC50 of 70.2 μg/mL. Thin layer chromatography (TLC) and gas chromatography-mass spectrometry (GC-MS) revealed the active component of each extracts. Notably, this is the first report on the AMPK activity of G. coronopifolia related to new blood vesselhttps://pharmatech.pharmaceuticalconferences.com/call-for-abstracts.php formation and a colorimetric-based correlation of angiogenesis based on Fe, Zn, and Cu concentration in the duck chorioallantoic membrane.

Speaker
Biography:

I, Sourav De, completed B. Pharmacy and M. Pharmacy in Pharmaceutical Chemistry from India at 2012. I have completed 5 yrs teaching and research experience in different University. I have already published few articles and two book chapters in different national and international journal. Now I am Pursuing PhD from VIT University, India. I am working on the basis on organometallic compounds, heterocyclic and QSAR modelling.  I have already delivered oral and poster presentation in different national and international conference. I am attaching my CV on the basis of above information.

Abstract:

A series of Ruthenium-Quinolinol complexes (3a-d & 4a-d) has been synthesized by employing a simple, efficient and environmental friendly condition. Catalytic role of Amberlite IRA-120(H) has been demonstrated. The structures of the new compounds were elucidated by the analysis of spectroscopic data. The stability of these complexes was measured by UV spectroscopy & time dependent NMR spectroscopy. These newly developed complexes were represented as potential anticancer agent. Complex [(η6-hexamethylbenzene)RuCl(κ2-O,N-5-chloro-HyQ)]·Cl (4b), [(η6-hexamethylbenzene)RuCl(κ2-O,N-5,7-dibromo-HyQ)]·Cl (4c) and [(η6-hexamethylbenzene)RuCl(κ2-O,N-5-chloro-7-iodo-HyQ)]·Cl (4d) exhibited best cytotoxicity profiles in three reported human cancer cell lines (MCF-7, Hela, Caco-2). A high selectivity was observed with these newly developed organoruthenium compounds in human cancer cell lines. Compound 4c might be utilized for cancer theranostic agents because of its significant quantum yield in water, high potency, selectivity and high cellular uptake in cancer cell lines.

Rashmi Pal

IFTM University, India

Title: A Review on Indoor air purifier plants
Speaker
Biography:

Rashmi Saxena Pal ,  assistant professor in Pharmacy deptt, PSIT, pursuing Ph D from IFTM University.  She has published more than 20 papers in reputed journals and has been serving as an editorial board member of reputed journals. She has attended many Conferences and Seminars and has e book publication in her account.She is life time member of APTI and have submitted many abstracts. 

Abstract:

The poor air quality of indoors  nowadays are responsible for the  major health problems, especially in children. Asthma is considered the most common chronic disease in urban-dwelling children.  Allergists consider  indoor air filtration to be part of a comprehensive measure to improve respiratory health. Air purifiers with HEPA filters have been shown to improve symptoms of asthma, allergies and other air borne infections. However, filtration systems and air purifiers do not reduce levels of all indoor air pollutants, therefore there is a need of addition of houseplants. The use of plants can be uniquely useful in these environments where other kinds of remediation technology may be impractical or difficult to deploy. In addition to basic photosynthesis that removes carbon dioxide and returns oxygen to the air, plants can remove toxicants from air, soil, and water. For maximal control over the elevated levels of mercury vapours, formaldehyde etc,  multiple species of houseplants are required. They should be planted  at the  sites  to remove the relevant toxicants in a particular space. The  houseplants are specific in the types of chemicals they are able to remove from the environment. The true potential of these indoor plants are yet to be explored and the  awareness regarding their benefits is to be  focussed upon. This review deals with the detailed study of some indoor plants such as Spider lily, Bamboo palm, Snake plant, Red edged Draceana,Boslon fern, Weeping fig, Rubber plant, Peace lily etc.

  • Pharmaceutical Biotechnology
Location: Hyatt Regency Osaka
Biography:

Xiaoling Wang is currently working as a associate professor in Capital Medical University located in Beijing the capital of China.

Abstract:

Introduction: HLA-B*15:02 has been demonstrated as a key risk factor for carbamazepine (CBZ) induced severe cutaneous adverse reaction (sCAR) especially in Asian population. Oxcarbazepine, a drug that has similar structure of CBZ. However, the HLA-B*15:02 is remained unknown for relationship of OXC induced cADR.

Method: 8 studies included for analysis, including 32 sCAR cases, 112 mild cutaneous adverse reaction (mcADR) cases, 281 OXC tolerant control, 946 population control.

Result: In tolerant control group, an association was between HLA-B*15:02 genotype and OXC induced sCAR (OR, 18.13; 95% CI, 6.77-48.56), but not in mcADR (OR, 1.43; 95% CI, 0.56-3.64). In population control group, the result is similar, in sCAR (OR, 8.22; 95% CI, 3.03-22.34), in mcADR (OR, 2.06; 95% CI, 0.91-4.67).

Discussion: Our study demonstrated that although OXC has a privilege compare to CBZ among sCAR, it might still share the similar genetic risk factor --HLA-B*15:02, on inducing sCAR.