Biplab Kumar Dey
Assam down town University, India
Title: Matrix diffusion controlled transdermal patches of an antihypertensive drug
Biography
Biography: Biplab Kumar Dey
Abstract
Transdermal drug delivery system is designed to transfer drugs through intact skin for systemic treatment. It offers controlled release of contained drug by a simple application to the skin's surface providing for more efficient drug utilization. In this research work, transdermal patches of Propranolol Hydrochloride were prepared as monolithic matrices by solvent casting technique. Both side opened glass moulds were wrapped with aluminium foil at one end onto which PVA backing and drug-polymer matrix were cast. Patches were formulated by using three polymers EC, PVP K30 and HPMC K4M in two combinations and in different proportions. Dibutyl phthalate (30 % w/w of polymer) and propranolol hydrochloride (20% w/w of polymer) in ethanol (10 ml) along with the polymers in requisite ratios were used to prepare the casting solution. All the prepared formulations indicated good physical stability when evaluated for thickness, weight variation, drug content, flatness, tensile strength, folding endurance, moisture content and water vapour transmission rate. Results of in-vitro permeation study revealed that the formulations prepared with least concentration of hydrophilic polymer blended with highest concentration of hydrophobic polymer (TTS6 and TDS6) have showed most extended drug release up to 48 hours through albino rat skin. It was observed that the drug release pattern was diffusion controlled when the data was fitted to various kinetic models. Result of in-vivo skin permeation study performed on male rabbit also confirmed that increase in hydrophobic polymer concentration blended with minimal hydrophilic polymer concentration have resulted in sustained release of the loaded drug from the transdermal patches.