Koushik Nandan Dutta
Assam Down Town University, India
Title: Effect of Mucuna pruriens (Linn) on acute dermal toxicity, electrocardiography and respiratory variable of Wister rat
Biography
Biography: Koushik Nandan Dutta
Abstract
Mucuna pruriens (Linn) is Known as velvetbean or cowitch found in Africa, India and the Caribbean belonging to the family Fabaceae.Mucuna pruriens Linn is a herbaceous vine, generally tap rooted and reproducing by seeds, leaves have three leaflets up to 15 cm long, densely hairy beneath and rather silvery the lateral leaflets asymmetrical. Hair lining of mucuna seeds were tested for acute dermal toxicity. Hair lining were mixed with dusting powder and prepared three formulation according to concentration. This test was performed on rats based on OECD guideline number 404 (OECD, 1981a). In case of acute dermal toxicity study there was no treatment related mortality in any of the groups following topical application of formulations in either male and female rats for 14 days .Hematological Studies revealed that after application of tested formulation WBC like monocyte, neutrophil, eosinophil were increased. Serum biochemistry data did not produce significant differences between control and treated groups of both sexes in the majority of cases.In case of electrocardiography the animals showed normal value as compared to the control group. In whole body plethysmograph the treated animals showed similar value as compared to the normal group . After Sacrifice, the gross examination of the vital organs like liver, kidney and lungs, no noticeable hemorrhage and abnormal conditions were observed. The histopathological study did not showed any type of abnormality of skin in all treated group. It can be concluded from the finding of the present study that the findings of these studies support the safety use of the test substance Mucuna pruriens.