Mohamed Abbas Ibrahim
King Saud University, UAE
Title: Pellets As A Drug Delivery System: New Formulation Aspects
Biography
Biography: Mohamed Abbas Ibrahim
Abstract
The interest in pellets as dosage forms has been increasing continuously. Several therapeutic advantages could be achieved using pellets as drug delivery system, over the single-unit regimen, such as less irritation of the gastro-intestinal tract and a lowered risk of side effects due to dose dumping. It has been shown that the rheological properties of wet masses can be successfully monitored by a mixer torque rheometer. It was shown that the rheological properties of wet mass could affect the release patterns from pellet formulations.
Different authors utilized pellets and granules controlled drug delivery systems techniques, which do not involve using organic solvents or coating, due to stringent global requirements of product safety. By developing matrix sustained release system one predominantly save time and money by omitting the coating operation. Monitoring the coating process by determining the amount of drug or color deposited is tedious, and often, encountering large variability. In addition, several attempts have been made to modify drug release from multi-particulate oral dosage forms by incorporating various hydrophobic materials into a basic formulation for pellets. Such systems retard the penetration of aqueous fluids into the formulation and hence slow the rate of drug release.
On the other hand, hydrophilic excipients can be incorporated to the pellets' wet mass so as to enhance the drug dissolution, giving advantages in addition to lowering the drug GI irritation and presenting homogenous drug absorption.