Biography
Biography: Adiel Coca
Abstract
Numerous applications have been reported for the tetrazole ring including being used as bioisosteres for carboxylic acids. In addition, several approved angiotensin II receptor antagonists that treat hypertension and congestive heart failure contain a tetrazole ring such as losartan, irbesartan, olmesartan, candesartan, valsartan and fimasartan. Some tetrazole derivatives have also been studied as propellants in airbags as well as in pyrotechnics and explosives due to the tendency of the tetrazole ring to decompose and release nitrogen gas under high heat. Our work involves the synthesis of 5-substituted 1H-tetrazole derivatives through the (3+2) cycloaddition of sodium azide with an organonitrile catalyzed by rare-earth metal catalysts. The reactions were carried out in an aqueous solvent mixture utilizing microwave heating. The antibacterial properties of tetrazole-containing compounds were also studied against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa.