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Xiaoling Wang

Title: Association between HLA-B*15:02 and Oxcarbazepine induced cutaneous adverse reaction: a meta-analysis

Biography

Biography: Xiaoling Wang

Abstract

Introduction: HLA-B*15:02 has been demonstrated as a key risk factor for carbamazepine (CBZ) induced severe cutaneous adverse reaction (sCAR) especially in Asian population. Oxcarbazepine, a drug that has similar structure of CBZ. However, the HLA-B*15:02 is remained unknown for relationship of OXC induced cADR.

Method: 8 studies included for analysis, including 32 sCAR cases, 112 mild cutaneous adverse reaction (mcADR) cases, 281 OXC tolerant control, 946 population control.

Result: In tolerant control group, an association was between HLA-B*15:02 genotype and OXC induced sCAR (OR, 18.13; 95% CI, 6.77-48.56), but not in mcADR (OR, 1.43; 95% CI, 0.56-3.64). In population control group, the result is similar, in sCAR (OR, 8.22; 95% CI, 3.03-22.34), in mcADR (OR, 2.06; 95% CI, 0.91-4.67).

Discussion: Our study demonstrated that although OXC has a privilege compare to CBZ among sCAR, it might still share the similar genetic risk factor --HLA-B*15:02, on inducing sCAR.