Mai Khanfar
Title: Enhancement Of The Release Of Curcumin By Freeze Drying Technique Using Inulin And Neusilin As Carriers
Biography
Biography: Mai Khanfar
Abstract
Curcumin solubility at physiological pH (6.8) was significantly increased by preparing solid dispersion (SD) with Inulin and Neusilin US2 at different ratios using Freeze-dry technique. Based on the results of differential scanning calorimetry and X-ray diffraction studies, Curcumin was presented in its amorphous state in formulations containing Neusilin US2. Formulation that contain Curcumin, Inulin and Neusilin US2 at ratio (1:5:1) gave the best enhancement in Curcumin dissolution, about 98% of Curcumin was released compared with 21% from raw material. Moreover, physical stability tests showed that Curcumin remained in its amorphous form after 3 months.